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Longer-term data from the XENDOS trial demonstrated that orlistat 120 mg (prescription strength), combined with lifestyle intervention, reduced the progression from impaired glucose tolerance to type 2 diabetes compared with lifestyle intervention alone

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Notably, female patients and those aged 4564 years demonstrated directionally lower risks compared with their counterparts, although these findings did not reach statistical significance

doi: 10.1038/s41579-020-0433-9 8 GruppenEGGarciaEConnellyMAJeyarajahEJOtvosJDBakkerSJLet al