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Carnitine and gamma-butyrobetaine stimulate elimination of meldonium due to competition for OCTN2-mediated transport

However, in the Smn +/ mice which is a mouse model of mild forms of SMA, muscle strength was maintained because the loss of motor neurons was compensated by sprouting from remaining motor axon terminals[43]

Much of the current evidence is preclinical (cell and animal studies), and human data is still limited