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Nevertheless, the study fails to clarify differences in serum PCS levels among PBC patients at different disease stages, uses non-human primary Kupffer cells in vitro , and does not evaluate the safety threshold for clinical PCS supplementation, which limits its therapeutic translation

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Retinoids temporarily disrupt the stratum corneum barrier, which is why clinicians recommend against layering other actives early in the process

Response: As discussed in more detail in section XX of this final rule regarding the adoption of a measure suppression policy, we note that the suppression of the Electronic Case Reporting measure merely excludes a measure from being assessed for performance

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