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Either by EBV primoinfection or infection by another pathogen that decreases CD4 T-cell responsiveness would increase the number of EBV-latent cells in different tissues, as EBV type I latent B cells are only controlled by EBNA-1-specific CD4 T cells (123125)

Yes, but the conversion is not one-to-one

For patients with heart disease, it remains a clinically superior choice over newer, less-studied drugs

However, our model also suggested that this third ureido residue could mimic the fourth amino acid residue (X4) by changing the substitution pattern (shift to the second methylene-C)

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