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It is recommended to use it for at least 3-4 months

10.1016/j.freeradbiomed.2021.12.268 11 ChenS.ChenY.ZhangY.KuangX.LiuY.GuoM.et al (2020a)

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Unknown long-term profile: Human safety data for this blend is limited, so caution and monitoring are advised

However, there are some indirect evidences supporting that inhibition of HDAC by VPA can enable methylated DNA to be more accessible to DNA demethylase, leading to DNA demethylation [135], which suggests that the induction of the methylation of Scn3a promoter by VPA is likely to be affected by the regulation of HDAC