Total oxidant capacity levels decreased and total antioxidant capacity levels increased in the hippocampus of aged rats treated with L-carnitine
PubMed Central, Hildebrandt, Wulf, et al
The same research group also published a study in older adults with HIV showing similar benefits, including reduced oxidative stress and improved mitochondrial fatty acid oxidation (Kumar et al., Antioxidants, 2020) [30]
Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)
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however, its relevance in human MASLD or metabolic HCC remains to be established
