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In 1980 Jean-Pierre Raufman, a young gastroenterologist (figure 33), and John Pisano, a biochemist at the National Institute of Health with a fascination for venoms, began investigating the effect of peptides found in the saliva of the lizard on human physiology
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Elevated resting heart rate in a dose-dependent pattern, most pronounced at higher doses Reduced systolic and diastolic blood pressure across all dose groups No significant increase in major adverse cardiovascular events including heart attack or stroke No reported cases of serious arrhythmia directly attributed to the drug in the trial population Mild palpitations reported by some participants, consistent with the heart rate increase The palpitation reports are worth noting
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