4.3.2 Evidence from preclinical models Preclinical studies using diabetic animal models, including db/db mice, have demonstrated that TCM interventionsparticularly polyphenol extractscan significantly attenuate renal injury, as evidenced by reduced urinary protein excretion and improved glomerular morphology (140, 148)
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doi: 10.1016/j.rbmo.2021.06.019 71 SugishitaYTaylanEKawaharaTShahmurzadaBSuzukiNOktayK
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These drugs, like semaglutide and tirzepatide, have been rigorously tested over years of clinical human trials and have been FDA approved to treat obesity
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