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However, whether circulating or local concentrations of endogenous PACAP [138] are increased in the presence of a DPP4 inhibitor or altered in Dpp4 / mice remains unclear, and it is difficult to ascertain due to the low concentrations of PACAP isoforms in vivo

A 2003 meta-analysis of 21 trials found that ALCAR was superior to placebo in several psychometric tests assessing global patient functioning, attention, memory, and some intellectual functions (105)