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RETATRUTIDE (GLP/GIP/GLUCAGON) Mecanismo de accin: Retatrutida es un agonista triple que activa GLP-1, GIP y el receptor de glucagn, diseado para imitar tres hormonas clave del metabolismo

Semaglutide and nonarteritic anterior ischemic optic neuropathy

Scott Isaacs, MD, FACP, FACEs Post Reduced-frequency GLP-1 as a maintenance strategy: in this case series, patients who tapered from weekly semaglutide/tirzepatide to less frequent dosing maintained weight loss, body composition, and metabolic syndrome gains, supporting structured de-escalation to lower burden without sacrificing efficacy

However, the core downstream target genes mediating Nrf2-regulated DR iron metabolism and lipid peroxidation lack in-depth validation, and the optimal activation strategy, long-term safety of Nrf2 pathway and its crosstalk with other ferroptosis regulatory pathways remain insufficiently studied, warranting further investigation

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