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The Kings College criteria system is the most commonly used for prognosis (Table 4)

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120 Upon activation, Nrf2 is shuttled into the nucleus, where it binds to the antioxidant response element and enhances the expression of antioxidant genes

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A greater than 40% increase in Memo expression has been linked to adverse clinical parameters in primary breast cancer and serves as an independent prognostic marker for early distant metastasis [121]