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Am J Kidney Dis 79(2):244256.e1

Beyond appetite suppression, GLP-1 RAs improve systemic glucose homeostasis through pancreatic and extra-pancreatic mechanisms

This typically includes periodic assessment of weight loss progress, tolerability of the medication, and screening for potential complications

This is particularly concerning during the first few weeks on a new dose when the effect can be surprisingly strong

Commercial insurance coverage for GLP-1 weight-loss medications has expanded in 2024-2026 - many large employers added coverage - but coverage remains uneven and typically requires prior authorization for obesity indications