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This when in the skin, it works by acting inside the skin cells to decrease the release of these whitening substances

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Journal of Physiology-Paris , 91, 173-178

Randomised Controlled Trials Two multicentre, randomised, double-blind and placebo-controlled trials assessed controlled-release afamelanotide implants in European and United States participants

An expected consequence would be that administration of ezetimibe to people who take warfarin (a vitamin K antagonist) would potentiate the warfarin effect