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Zhais team (Zhai et al., 2020) found that exendin-4, a GLP-1 receptor agonist, enhances eNOS activity and NO production, which helps relax retinal capillaries and restore microvascular perfusion in ischemia-reperfusion (I/R) injury models

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The use of an anti-human GIPR antibody (hGIPR-Ab) replicated these results in obese non-human primates (NHPs), with an even more pronounced weight loss observed than in mice

Pancreas 27 , 122126 (2003)