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Preclinical and clinical studies have demonstrated that GLP-1 receptors expressed in myocardial and vascular endothelium tissue play a fundamental role in the cardioprotective effect of GLP-1 RAs, lowering the risk of major cardiovascular events, heart failure, and kidney complications in adults with and without diabetes [4]

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The once-weekly injection model also provides stronger behavioral cues for adherencemany people find it easier to remember one specific day per week than daily intake requirements