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Therefore, in advanced patients, careful dose adjustments are necessary to reduce proteinuria while maintaining renal perfusion (Podest et al., 2023

These methods enable computers to act autonomously, without the need for explicit programming, by developing algorithms that learn from data and make informed decisions or predictions 38,39

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In line with these findings, deletion of GLP-1Rs in paired-like homeobox 2b (PHOX2B)-expressing neurons, which mark all vagal sensory afferents, minimally affects the acute appetite suppressing effects of exendin-4 and only partially prevents the weight loss caused by chronic treatment with the GLP-1R agonist dulaglutide [35]

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