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d/b/a Gala GLP-1
We propose that the effects of cumulative loss of surface receptor with fast-internalizing, slow-recycling, lysosome-targeting agonists, along with increases in -arrestin-induced desensitization, become more apparent with time, eventually overriding any positive effects associated with noncanonical signaling
Think of it as turning down two dials simultaneously
Khi u: Nghin cu mi nht cho thy thuc GLP-1 cng c th ng mt vai tr nht nh trong iu tr khi u
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The precise mechanisms for this effect are unclear
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