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Glossary PF pulmonary fibrosis TCM traditional Chinese medicine ROS reactive oxygen species PUFAs polyunsaturated fatty acids GSH glutathione GPX4 glutathione peroxidase 4 BLM bleomycin AECIIs alveolar epithelial type II cells NADPH nicotinamide adenine dinucleotide phosphate NOXs NADPH oxidases XO xanthine oxidase NOS nitric oxide synthase TGF-1 transforming growth factor-1 NOX4 NADPH oxidase 4 NLRP3 NOD-like receptor thermal protein domain-associated protein 3 AA arachidonic acid ACSL4 acyl-CoA synthetase long chain member 4 LPCAT3 lysophosphatidylcholine acyltransferase 3 LOXs lipoxygenases PUFA-OOH polyunsaturated fatty acid hydroperoxide IL-4 interleukin-4 IL-13 interleukin-13 CAT catalase SOD superoxide dismutase MDA malondialdehyde SLC7A11 solute carrier family 7 member 11 MAPKs smitogen-activated protein kinases ERK extracellular signal-regulated kinase JNK c-Jun N-terminal kinase NF-B nuclear factor kappa-B Nrf2 nuclear factor erythroid 2-related factor 2 NCOA4 nuclear receptor coactivator 4 LIP labile iron pool DHQ dihydroquercetin CTGF connective tissue growth factor LOX2 lipoxygenase 2 TNF- tumor necrosis factor alpha NO nitric oxide IL-1 interleukin-1 IL-6 interleukin-6 HO-1 heme oxygenase-1 DHA dihydroartemisinin -SMA -smooth muscle actin H&E hematoxylin and eosin AECs alveolar epithelial cells MSCs mesenchymal stem cells hMSCs human MSCs DSP desmoplakin CD5L CD5 molecule-like USP11 ubiquitin-specific protease 11 3D three-dimensional AI artificial intelligence cfDNA circulating free cell DNA DAMPs damage-associated molecular patterns PDGF platelet-derived growth factor MMP-9 matrix metalloproteinase-9 EMT epithelial-mesenchymal transformation ECM extracellular matrix References 1 AlessandroA.Anna MartinaB.AlessandroS.LaviniaP.EmanueleG.SeleneB.et al (2024)

Even glutathione, the protective nutrient preserving the quality of spermatozoa, isnt immune to stressful periods

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