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The following gRNA target sequences were employed to generate ARL8 DKO cell line: sgRNA for ARL8A : CGCGATCACGTTGACGAAGG, and sgRNA for ARL8B : AGAGATGGAGCTGACGCTCG 20

doi:10.1002/hipo.20470 124

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An ROS-responsive artesunate prodrug nanosystem co-delivers dexamethasone for rheumatoid arthritis treatment through the HIF-1/NF-B cascade regulation of ROS scavenging and macrophage repolarization

Future work will explore further optimization of drug release kinetics, long-term safety across larger animal models, and eventual clinical translation of this technology for type 2 diabetes and metabolic disorders

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