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Walking 30 to 60 minutes daily is the simplest and most sustainable approach

Most patients require long-term or indefinite GLP-1 therapy to maintain benefits, as discontinuation typically results in weight regain and worsening metabolic parameters

470 One could argue that the success of sodium-glucose cotransporter 2 (SGLT2) inhibitors, and now of GLP-1RAs, suggests that metabolic abnormalities play an important role in driving HFpEF

K.et al (2017)

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a higher-dose prescription version (orlistat 120 mg, Xenical) is also available