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In Parkinsonian rat models, ALC improved glutathione (GSH) content while decreasing oxidative stress indices and inducible nitrogen oxide synthase (iNOS) levels.[15] Combination Strategies for Oxidative Stress: ALC 1,500-2,000 mg/day + Alpha-lipoic acid 600 mg/day (complementary antioxidant mechanisms) + N-acetylcysteine 600-1,200 mg/day (glutathione precursor) + Vitamin E 400-800 IU/day (lipid-soluble antioxidant) 5

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Under usual circumstances, the metabolism of homocysteine contributes to both the methionine and GSH synthesis pathways

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