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In order to mitigate these off-target effects, we sought to perform our pooled functional depletion screenings against sublethal doses of APR-246

Later studies have reported weight loss approaching 28% in some participants, which is comparable to results sometimes seen with bariatric surgery

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Stopping Mounjaro does not require tapering for safety reasons , but doing so under medical guidance can help manage appetite changes, weight maintenance strategies, and blood sugar control

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