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Further research by Yin et al

An additional concern when initiating immunotherapy is the approach to patients with known autoimmune disease, who may be at risk for a flare of their illness, and thus may not be offered ICIs

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Particular consideration may be in the interaction with many molecular pathways [3,4,5,6,20,22,50,51,52,53,54,55,56,57], taking as evidence the BPC 157/NO-systems particular importance (i.e., the endothelium and thrombocytes function both maintained (for review, see, i.e., [2,3,4,5,6,7,8]))

Addressing these areas will not only deepen the understanding of ferroptosis in ADPKD but also accelerate the translation of targeted strategies into effective, safe therapies for this common hereditary kidney disease

6 Thus, APR-246 is one of the most promising compounds in clinical development for TP53 mutated cancers