Basic and clinical pharmacology of glucocorticosteroids
[64] Hesperidin upregulates cholecystokinin (CCK), one of the gastrointestinal enzymes related to GLP-1 activity (refer to the graph in our introduction to this article if you need a refresher)
Now, why GLP Ones become part of this conversation is because these medications have strong evidence for improving insulin sensitivity
It functions as a dual GIP (Glucose-dependent Insulinotropic Polypeptide) and GLP-1 (Glucagon-like Peptide-1) receptor agonist, a mechanism that enhances both insulin secretion and sensitivity while regulating appetite and metabolism
Ottman N, Davids M, Suarez-Diez M, et al
Poor sleep disrupts hormones related to hunger and satiety, potentially hindering weight loss