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Interleukin-1 beta (IL-1), Interleukin-6 (IL-6), and Tumor Necrosis Factor-alpha (TNF-) are key pro-inflammatory cytokines involved in immune responses and inflammation

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The actual mechanism of MIS-C/A still needs more research, but there are a few hypotheses

References 1 GoreACChappellVAFentonSEFlawsJANadalAPrinsGSet al

In line with these findings, a mediation analysis revealed that increased DNA methylation of the principal adipogenic transcription factor GC1 gene locus in the placenta, responsible for glucose and lipid metabolism, was correlated with higher leptin levels in the cord blood of offspring exposed to maternal hyperglycemia in the second trimester [75]

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