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Its simultaneous activation of three receptor pathways GLP-1R for appetite suppression and insulin secretion, GIPR for augmented insulin response and central appetite modulation, and GCGR for energy expenditure and hepatic fat mobilisation produces metabolic effects that exceed what single or dual agonism can achieve [4][8][9]

Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed

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According to the drug label, Mounjaro is most likely to reduce birth control efficacy after the first dose, with this potential side effect diminishing over time