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And the march for an even better GLP-1 drug continues

Impact of systemic therapies in metastatic melanoma of unknown primary: a study from MELBASE, a French multicentric prospective cohort

explored the effect of bergaptol on cellular melanogenesis and found that it may increase melanin synthesis in B16F10 melanoma cells by regulating the p-P38 and p-ERK signalling pathways [265]

However, since CD38 could be expressed by other immune and non-immune cells 60,61 , our results suggest that the efficacy of targeting CD38 might not solely rely on CD38 expression level in T cells, opening up additional therapeutic opportunities

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