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Fortunately, although most tumor cells have developed resistance to apoptosis, they surprisingly exhibit high sensitivity to ferroptosis ( 4.1 The mechanisms underlying the sensitivity of tumor cells to ferroptosis Early researchers discovered that tumor cells exhibit high sensitivity to ferroptosis ( 4.1.1 PUFA content of tumor cell membranes The expression of various PUFA synthesis enzymes is upregulated in most tumor cells

Abbreviations : DTE, Drug-Targeting Efficiency

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Therapeutic payloads, such as gene therapy vectors or immunomodulatory, can also be incorporated into the MSNs structure, functionalized modifications, allowing combination therapies or targeted immune modulation