Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations
Other risk factors include age, digestive issues like Crohns disease, or medications that interfere with B12 absorption
In those cases, imaging may become relevant when pain is persistent, mechanical, worsening, or limiting progress
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Both symptoms share the same root cause: slowed GI motility from GLP-1 receptor activation
These conclusions are generally based on moderate increases in LPO parameters, reduced hepatic GSH content, a decline in GPx4 protein levels, and an increase in ACSL4