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Studies show that while there may be a little cognitive decline in the first half of life, it generally begins around age 50 and is most pronounced at age 70 and on

Effect of vitamin D therapy on urinary albumin excretion, renal functions, and plasma renin among patients with diabetic nephropathy: a randomized, double-blind clinical trial

2 Neurodegenerative disorders 2.1 Alzheimer's disease (AD) Evidence indicates that gut microbiota composition is altered in AD, with a trend toward reduced diversity and specific bacterial taxa linked to disease severity

6) Ongoing Phase 3 for cardiovascular endpoints (REDEFINE-3 CV outcomes)

Nature 460:831838