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HR: 0.62, 95% CI: 0.460.84)

For non-diabetic obesity, the cleanest comparison is between two separate trials: STEP 1 (semaglutide 2.4 mg, Wilding et al., NEJM 2021): 14.9% body weight loss at 68 weeks SURMOUNT-1 (tirzepatide 15 mg, Jastreboff et al., NEJM 2022): 20.9% body weight loss at 72 weeks A roughly 6 percentage point gap in average weight loss favors tirzepatide

Approximately three-quarters of patients initiating oral Wegovy had not previously received a GLP-1 injection, according to NorstellaLinQ data When available quickly, claims and EMR data do what claims data alone cannot