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doi: 10.3389/fimmu.2022.864007 5 MathurNMehdiSFAnipindiMAzizMKhanSAKondakindiHet al

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InChi Code: InChI=1S/C12H19N3O7S/c1-6(16)23-5-8(11(20)14-4-10(18)19)15-9(17)3-2-7(13)12(21)22/h7-8H,2-5,13H2,1H3,(H,14,20)(H,15,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1

This produces hydrogen peroxide (H2O2), which decreases the activity of the dihydropteridine reductase (DHPR) enzyme.71,72 Furthermore, H2O2 negatively affects acetylcholinesterase (AchE) and xanthine oxidase (XO).73,74 Repair mechanisms and immune system activation in vitiligo patients could reduce the risk of skin cancer, which is attributed to immune activation capable of identifying and eliminating damaged cells, including those with potentially precancerous mutations

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Hence, besides biochemical evidence for the reduction of the intramolecular disulfide formed in the C-terminal domain of APR by GSH, additional evidence for other redox regulatory mechanisms remain scarce