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The synergy rationale extrapolates from: (1) documented synergy between GHRH and various GHRPs (particularly GHRP-6) across multiple species and systems, (2) individual characterization of CJC-1295 No DAC showing 49-fold potency enhancement, (3) individual characterization of Ipamorelin showing comparable potency to GHRP-6 but with superior selectivity, and (4) established mechanistic principles of complementary receptor pathway activation

Ann N Y Acad Sci 2004;1033:158-67

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doi:10.2337/db09-0047 Padilla A, Descorbeth M, Almeyda AL, Payne K, De Leon M (2011) Hyperglycemia magnifies Schwann cell dysfunction and cell death triggered by PA-induced lipotoxicity

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