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Retatrutide trials have focused on adults with a BMI of 30 kg/m or above, but many groups including pregnant individuals, those with pancreatitis history, and under-18s are excluded, making individual clinical assessment essential

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Rrf2 Rrf2 repressors are dimers consisting of an N-terminal DNA-binding winged helical domain composed of five helices and two -strands, and a C-terminal helical dimerization domain dominated by a long helix, and thus superficially resemble MerR-family activators (Section 3.2.3)

Addiction, psychiatric side effects, and cardiovascular damage overshadowed their modest benefits