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The original 2015 Cell Metabolism study demonstrated that intraperitoneal MOTS-c injections (5 mg/kg) in mice fed a high-fat diet prevented obesity and insulin resistance, with effects on fat mass, fasting glucose, and insulin sensitivity that rivaled pharmaceutical intervention [1]

Adebomi V, Cohen RD, Wills R, Chavers HAH, Martin GE, Raj M (2019) CyClick chemistry for the synthesis of cyclic peptides

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however, its impact on nutrient absorption necessitates a proactive approach to maintaining vitamin levels