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Collectively, all GLP-1 receptor agonists, including native GLP-1, peptides, and small molecule GLP-1 receptor agonists, stabilize the binding pocket of the GLP-1 receptor in a similar fashion, which induces the TM helices 6 kink, a distinctive feature of the active state of the class B1 GPCR

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Rapid weight loss changes estrogen levels, and the hormonal shifts that accompany significant fat loss can temporarily alter cycle timing, flow, and symptoms

doi: 10.3389/fendo.2025.1613334 Received 17 April 2025 Accepted 15 August 2025 Published 02 October 2025 Volume 16 - 2025 Edited by Hong Liu, UC Davis Health, United States Reviewed by Andrei Adrian Tica, University of Medicine and Pharmacy of Craiova, Romania Tian Xia, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, China Updates Copyright 2025 Ou, Wang, Zhou, Chen, Lyu, Feng and Huang