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22,23 Obese HFpEF patients have greater LV hypertrophy and pulmonary capillary wedge pressure, increased LV filling pressures and severe right ventricular dysfunction compared with non-obese HFpEF patients

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While some people can tolerate daily use, kojic acid soap can be drying and irritating if used too frequently

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However, dose adjustments may be necessary to prevent hypoglycemia, particularly when used with insulin or sulfonylureas

Require immediate conventional treatment (surgery, injections, laser)