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Because common GI side effects like nausea, constipation, and fatigue are often related to dose size, starting with a lower dose may help reduce the chances of feeling uncomfortable

These side effects typically resolve without the need for medical intervention

doi:10.1111/j.1532-950x.2003.00515.x

The proopiomelanocortin and cocaine- and amphetamine-regulated transcript neurons get activated

When glutathione levels drop, the immune system effectively "loses its brakes," allowing for the overproduction of pro-inflammatory cytokines like Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-)

Zelniker TA, Wiviott SD, Raz I et al (2019) SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials