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INTRODUCTION GLP-1 RA such as semaglutide and tirzepatide have found increasing use for weight management due to potent effects on weight reduction through delayed gastric emptying and appetite modulation

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Additionally, increased plasma insulin, decreased triglycerides, and improved myocardial glucose uptake were observed in the GLP-1 treated group [74]

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How tirzepatide addresses cardiovascular risk The Jorge 2026 study demonstrated that GLP-1 receptor agonists were associated with significantly lower risks of major adverse cardiovascular events in lupus patients compared to DPP-4 inhibitors