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Clinical trials have found they help reduce major cardiovascular events in people with obesity, reduce sleep apnea and also lower the risk of kidney disease

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Neurological symptoms include meningitis, encephalitis, radiculopathy, peripheral neuropathy, intracerebral abscesses, and acute or chronic neck rigidity ( 95%)

The goal of treatment is to relax dietary restrictions as much as possible while blood Phe levels maintain within range

NAD+ also declines with age

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