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Annu Rev Nutr 1992

Similar to the biochemical properties of MDA, biological 4-HNE also exists in two forms, including free 4-HNE or adducted 4-HNE with proteins, nucleic acids, lipoproteins, and amino acids (152)

Pathological validation of the MDS criteria for the diagnosis of multiple system atrophy

Increasing the reduces the mitochondrial [NAD + ]/[NADH] that may slow aging (Berry et al., 2023a,b) by both enhancing SLC25A12 and SLC25A13 activity to increase MAS activity and by creating thermodynamic back-pressure to slow ETC complex I-mediated proton pumping