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Intracellular GSH levels were elevated in all five donor samples following melatonin treatment ( Figures 8D, E ), whereas co-treatment with IKE prevented this accumulation ( Figures 8D, E )

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The New England Journal of Medicine

Ultimately, 706 participants met the eligibility criteria and were randomly assigned to one of several treatment arms: once-weekly subcutaneous injections of Cagrilintide at doses of 0.3, 0.6, 1.2, 2.4, or 4.5 mg, once-daily liraglutide 3.0 mg, or a volume-matched placebo