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Notably, -syn binds TLR2 on microglia, promoting TNF- release and indirectly enhancing neuronal DNA damage [80]
Indeed, reduced expression of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) enzymes has been described in obesity ( Several studies have addressed the relationship between zinc status and the changes in obesity in animal models and obese individuals ( 3 Zinc: an essential micronutrient The importance of zinc to human health has been increasingly appreciated since the first evidence by Prasad ( Figure 1 )
doi: 10.1136/ard-2023-224762 111 AthanassiouPAthanassiouL
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10.1016/j.foodchem.2020.126840 Food Chem
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