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The study, led by Astrup A and Madsbad S, involved obese subjects who received different doses of Tesofensine or a placebo for 24 weeks

When activated, mast cells release a cascade of inflammatory mediators, including: This can disrupt the BBB, promote leukocyte infiltration, and create a pro-inflammatory CNS microenvironment

It also modulates serotonin, dopamine, and norepinephrine in limbic circuits (Zozulia et al., Zh Nevrol Psikhiatr Im SS Korsakova 2008)

This can lead to improved metabolic function, better stress response, and enhanced overall hormonal balance

Staresinic et al

Meaning that we will likely see more compounding pharmacies who are making this stuff go down and also expect FTC to begin to take out online sellers