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JAKs activate the transcription factors of the STAT family which have a crucial role in cellular immunity, differentiation, and proliferation

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Similarly, DENV replication has been reported to be either enhanced or inhibited by NOX modulation 45,152 , suggesting a critical role of ROS in viral replication

Int J Mol Sci 20:5023 Bello AE, Perkins EL, Jay R, Efthimiou P (2017) Recommendations for optimizing methotrexate treatment for patients with rheumatoid arthritis

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