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The pharmacology of these two long-acting GLP-1 analogs, in terms of improving glycemic control, reducing body weight and decreasing cardiovascular (CV) risk, is also reviewed, together with some novel biology

GLP-1 receptor agonists like semaglutide slow gastric emptying and reduce gastric acid secretion

Temperature extremes pose additional risks

Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway

It also appears to be more potent and longer-acting than other GLP-1 receptor agonists