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OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universitt Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstrasse 74, 01307 Dresden, Germany

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To this end, we have used an FBA-based machine learning (ML) framework for studying altered metabolic reactions between patients with CD and controls, leveraging 'omics data from a public repository from the Risk Stratification and Identification of Immunogenetic and Microbial Markers of Rapid Disease Progression in Children with Crohn's Disease (RISK) study, one of the largest pediatric inception cohorts of children with a new diagnosis of CD, to identify biomarkers found in the blood or stool to help predict which children are at risk of developing complications 1,27