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A Skeptical Take of Semaglutide for Cardiac Protection A preventive cardiologist offers a critical appraisal of the SELECT trial of Semaglutide (Wegovy) When the New England Journal of Medicine published the placebo-controlled SELECT trial of semaglutide in patients with established vascular disease, I had thought cardiology had discovered another disease-modifying drug

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They do not undergo the same extensive stability testing that large pharmaceutical manufacturers conduct over years of development