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In the meanwhile, the incidence rates of gastrointestinal disorders, such as vomiting, nausea, constipation, loss of appetite and diarrhea were comparatively higher than those in the placebo, with the risk ratios of 3.79 (95% CI 277 to 519), 282 (256 to 311), 266 (211 to 336), 225 (146 to 346), and 190 (165 to 219), respectively ( Figures S2125 )

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