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studies examining GH effects on IGF-1 without hypothalamic-adrenal axis confounding

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Here is how it works: the enzyme carnitine palmitoyltransferase I (CPT-I) on the outer mitochondrial membrane converts fatty acyl-CoA to fatty acylcarnitine by attaching it to a carnitine molecule

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This Glp phenotype was not as severe as that observed with glp-1(null) mutants as the progenitor zone did not become fully depleted until later in larval development, and depletion did not fully occur at higher temperatures (Crittenden et al., 2002

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